1975 First researcher to clone HIV and complete a genetic mapping of the virus

Wong-Staal was the first scientist to clone HIV and determine the function of its genes. This was a major step in proving that HIV is the cause of AIDS; it showed the amount of TAT proteins within a cell infected by HIV-1 is directly correlated to the number of Kaposi's sarcoma lesions a patient may have. This was essential in developing new treatments for HIV/AIDS patients with lesions. Wong-Staal continued her research into gene therapy, using a ribozyme "molecular knife" to repress HIV in stem cells. The protocol she developed was the second to be funded by the United States government. In 1990 a team of researchers led by Wong-Staal studied the effects that the Tat protein within the viral strain HIV-1 would have on the growth of cells found within Kaposi's sarcoma lesions commonly found in AIDS patients.

Cloning & expression of HIV-1DNA; Mo;ecu;lar cloning of HIV-1 from immortalized cellline; Cloning & expression of HTLV-III DNA; Detection of HIV-1 DNA; Lentiviral nucleic acids & uses thereof; Antibodies against human herpes virus-6 (HHV-6) & method of use; Design of novel highly efficient HIV based package systems for gene therapy; Polypeptides encoded by novel HIV-2 proviruses; Cell transformation vector compromising an HIV-2 package site nucleic acid & an HIV-1 GAG protein; Retroviral vectors comprising an anti-HIV or other nucleic acid; HIV-specific ribozymes; Nucleic acid encoding HIV-1 TAT protein; Productive of human T-cell leukemia (lymphotropic) retrovirus (HTLV-1) envelope protein fragments in bacteria & use in seroepidemiological studies; Viral vectors; Increasing rAAV titer; Method for detecting inhibitors of TAT protein; Characterization of replication competent human immunodeficiency type 2 proviral clone HIV-2.subsSBL/ISY; Expression of immunologically active proteins of human.beta.-lympho tropic virus; In situ detection of human T-cell leukemia virus type III; Plasmid & phage clones of human T-cell lymphotropioc virus type III; Molecular cloning & clones of human 6 lymphotropic virus (hblv); Sor gene product from human T-cell lymphotropic virus III; Retroviral vectors expressing soluble CD4: a gene therapy for AIDS; Plasmids which inhibit human t-cell lymphotropic virus type III replication; Immunochemical reagent; Isolation & purification of the R18 antigen of HTLV-III

Category:
Biology - Microbiology, Virology

Completion Status:
yes

Patent Number:
9328391;9309574;8785609;7815916;6858712;6610476;6555107;RE38824;6323019;6235881;6200811;61329962;6077935;6054283;6018027;6001977;5958768;5883081;4963497;4772547;CA1341366C;AU2003254151B2;AU702266B2;AU647013B2;AU594444B2;AU612315C;5063053

Co-Inventor:
Eric M. Poeschla; David J. Looney;Syed ZakiSalahuddin; Dharam V. Ablaski; Steven F. Jacobs; Carl W. Saxinger; Peirre Corbeau; Gunter Kraus; Randy L. Talbot; Mang Yu; Osamu Yamada; Joshua O. Ojwang; Marley C. Leavitt; anthony Ho; Nancy T. Chang; Robert C. Gallo; Mikulas Papovic; Beatrice H. Hahn; George M. Shaw; Amanda G. Fisher; William Alan Haseltine; Craig A. Rosen; Joseph Gerald Sodroski; Suresh K. Arya; Takis S. Papas; Kenneth Samuel; James A. Lautenberger; Michael Mamounas; Jay Rappaport; James R. Rusche; Genoveffa Franchini; Pranab K. Chanda; John Ghrayeb; Edgar P. Heimer; Premkumar E. Reddy; Jon E. Chatterton; Ning Ke; Henry Li; W. French Anderson; Richard A. Morgan; Daryl Muenchau; Mark B. Feinberg; Michael L. Berman; Sylvia A. Crush;