2000 - Research in the use of biological micro-electromechanical systems to support cells outside the human body

* Bhatia’s research was one of the first projects at MIT of biological micro-electromechanical systems, or Bio-MEMS * Uses arrays of living cells as high-throughput platforms to study fundamental aspects of Bio-MEMS in stem cells * Her doctoral work focused on the development of a way to keep liver cells functioning outside of the human body *Adapted ideas from computer chip design and engineering to the microfabrication of a substrate for liver cells * Applied techniques from photolithography to petri dishes, to create a substrate that would support growth of a functioning microliver in a dish * Use of techniques from 3D printing to create a lattice of sugar as a framework for a synthetic vascular system with the goal of supporting larger tissue structures such as an artificial liver.

created human microlivers; in vivo enzyme profiling; profiled protease activity; multi-well micropatterning by ablation; devices for regeneration; inhalable nanosensors; see Doc Links for full list

Category:
Biological Engineering, Nanotechnology

Completion Status:
done

Patent Number:
11549947;11549951;11519905;11448643;11428689;11366103;11338065;11324858;11266766;11054428;11021529;10908151;10883998;10731125;10571461;10527619;10260039;10234449;10072257;10004826;1006916;9994809;9970941;9611453;9441202;9194841;9006415;8906684;8715436;8685638;8673267;8617815;8377147;7510637;7312046;6734000;5741228

Co-Inventor:
Gabriel A. Kwong; Geoffrey A. von Maltzahn; Jaideep S. Dudani; Ester J. Kwon; Andrew David Warren; Darrell J. Irvine; Karl Dane Wittrup; Naveen K. Mehta; Piyush K. Jain; Simone Schurle; David T. Eddington; Kelly R. Stevens; Christopher S. Chen; Jan D. Baranski; Ritika Chaturvedi; Michael T. Yang; Leslie Wan-Gee Chan; Melodi Nilgun Anahtar; Roderick Russell Kunz; Tal Danino; Arthur Prindle; Jeff Hasty; David K. Wood; Kevin Y. Lin; Cheri Y. Li; Alice A. Chen; Shengyong Ng; Elliot Hui; Salman R. Khetani; Bevin P. Engelward; David M. Weingeist; Yin Ren; Valerie Lui Tsang; Dirk Albrecht; Giovanni Vozzi; Christopher Flaim; Michael J. Sailor; Ji-Ho Park; Austin Derfus; Ester Segal; Kenneth S. Vecchio; Carrolee Barlow; Mihrimak Ozkan; Sadek C. Esener;Vicki I. Chin; Boyce E. Collins; Gregory H. Lambrecht; Joshua Makower; David McDonald; Ashish Khera; J. Christopher Flaherty; Alan K. Plyley; Russell J. Redmond; Claude A Vidal